To be honest, I'm quite surprised by the number of strict alphabeticisers (?!) and label run collectors. Surely this only works as a system if you know exactly what record you want to listen to - or feel like listening to a load of Okeh 45s or whatever?
My collection is sorted by genre, and if any sub-genres within are big enough they get their own sections. So, if I'm DJing I can go to the relevant box: 60s northern soul, 70s soul, disco, Motown, Kent, Blue Cat/Red Bird, funk, nu-funk, James Brown productions, Eddie Bo productions, jazz, girl groups, mod stuff, reggae/ska, new arrivals etc And plenty of genres which are of no interest to anyone on here!