Big venue = lowest common denominator - just HAS to be because of the number of different people you have to please (after all frankly there's A LOT of money at stake if you don't get the numbers) and if you don't have a reasonably full dancefloor in a giant venue it just feels absolutely dead (and remember that a full dancefloor in a huge venue could well mean the equivalent of the entire population of a 'normal' sized venue on the floor at the same time - a tough ask of any DJ) - so you HAVE to spin things everyone knows and likes coz if you lose the floor in a venue like this it's that much harder to win it back.
Personally I hate really big venues - I think people that need them just want to be cattle. Sadly I think many are simply desperate to be part of a 'gang' because they haven't the passion to be sure they're into the 'right' music/record without that mass affirmation (it's the same mindset that sees records that were bumping along with little interest suddenly explode into being 'universally' loved - king's new clothes).
For me you get a proper atmospheric buzz when everyone's kicking off each other in a tight venue with a like minded group musically (ie knowledgable, broad minded and accepting of stuff they don't know if it measures up - that counts whether it's a venue playing 60s club sounds, a newies/lesser known oldies, or a modern venue - I enjoy them all if they good).
Dx